Scientists
from Washington University School of Medicine in St. Louis have discovered bee
venom can kill the HIV virus without harming the body.
Bees
could hold the key to preventing HIV transmission. Researchers have discovered
that bee venom kills the virus while leaving body cells unharmed, which could
lead to an anti-HIV vaginal gel and other treatments.
Scientists
at the Washington University School of Medicine in St. Louis found that
melittin, a toxin found in bee venom, physically destroys the HIV virus, a
breakthrough that could potentially lead to drugs that are immune to HIV
resistance. The study was published Thursday in the journal Antiviral
Therapy.
Our
hope is that in places where HIV is running rampant, people could use this as a
preventative measure to stop the initial infection,” Joshua Hood, one of the
authors of the study, said in a statement.
The
researchers attached melittin to nanoparticles that are physically smaller than
HIV, which is smaller than body cells. The toxin rips holes in the virus’ outer
layer, destroying it, but the particles aren’t large enough to damage body
cells.
“Based
on this finding, we propose that melittin-loaded nanoparticles are well-suited
for use as topical vaginal HIV virucidal agents,” they write.
Theoretically,
the particles could also be injected into an HIV-positive person to eliminate
the virus in the bloodstream.
Because
the toxin attacks the virus’ outer layer, the virus is likely unable to develop
a resistance to the substance, which could make it more effective than other
HIV drugs.
“Theoretically,
melittin nanoparticles are not susceptible to HIV mutational resistance seen
with standard HIV therapies,” they write. “By disintegrating the [virus'] lipid
envelope [it's] less likely to develop resistance to the melittin
nanoparticles.”
The
group plans to soon test the gel in clinical trials.
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